Structure and Composition

• Complex glycoprotein with dimeric/multimeric structure
• Contains three repeating units: Type I, II, and III modules
• Features unique EDA and EDB domains through alternative splicing

Synthesis and Secretion

• Locally produced by fibroblasts and endothelial cells
• Undergoes post-translational modifications in reticulum
• Can either attach to cell membrane or integrate into ECM

Cell Adhesion and Migration Functions

• RGD sequence in Type III module interacts with integrin receptors
• Engages with α5β1 and αvβ3 integrins
• Controls cell attachment, spreading, and movement

Developmental and Disease Roles

• Essential for embryonic development
• Critical for wound healing in adult tissues
• Abnormal levels linked to cancer progression
• Excessive buildup associated with organ fibrosis

Therapeutic Applications

• Research focuses on modulating cFN levels
• EDA region inhibition shows promise for cancer/fibrosis treatment
• Engineered cFN fragments being developed for wound healing
• Targeted approaches aim to minimize side effects

Suitable ELISA Kits

• Cellular Fibronectin ELISA Kit