Humanin (MT-RNR2): A Mitochondrial-Derived Peptide with Cytoprotective and Metabolic Functions in Age-Related Diseases
Endocrinology Diagnostics
Key Summary of Humanin (MT-RNR2):
Molecular Characteristics
- 24-amino acid peptide from MT-RNR2 gene
- Consistent sequence across species
- Expression regulated by stress and aging signals
Cellular Interactions
- Binds CXCR4 and GPR30/GPER receptors
- Activates STAT3 and ERK pathways
- Enhances cell survival and metabolic efficiency
Cytoprotective Functions
- Protects neurons from neurodegenerative diseases
- Reduces oxidative stress
- Prevents cell death through anti-apoptotic mechanisms
Disease Associations
- Mitigates Alzheimer's and Parkinson's neurodegeneration
- Improves cardiovascular and metabolic health
- Potential variable effects in cancer biology
Therapeutic Potential
- Synthetic variants like S14G show improved stability
- Ongoing clinical trials for neurological and metabolic disorders
- Future research focuses on targeted delivery and molecular interactions
Suitable ELISA Kits
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