OGG1 (8-Oxoguanine DNA glycosylase) constitutes a DNA repair enzyme that removes oxidatively damaged guanine bases, initiating base excision repair to maintain genomic integrity. As one of the chief DNA lesions generated by reactive oxygen species, 8-oxo-7,8-dihydroguanine (8-oxoG) potently pairs with adenine instead of cytosine, causing G:C to T:A transversion mutations upon cellular replication.

ELISA kit information:

• Reactivity: Human
• Sample Type: Plasma, Tissue Homogenates, Serum, Biological Fluids
• Sensitivity: 0.094 ng/ml
• Target: N-Glycosylase, OGG1, 8-Hydroxyguanine, DNA Lyase, 8-Oxoguanine DNA Glycosylase, AP Lyase